نشریه علوم و مهندسی سطح

نشریه علوم و مهندسی سطح

رسوب‌دهی الکتروفورتیک ماتریس کیتوسان حاوی دوکسوروبیسین بر پوشش کلسیم فسفات حاصل از PEO روی داربست‌های Ti6Al4V برای درمان هدفمند سرطان استخوان

نوع مقاله : مقاله پژوهشی

نویسندگان
1 دانشکده مهندسی مواد، دانشگاه صنعتی اصفهان، اصفهان، ایران.
2 دانشکده شیمی، دانشگاه صنعتی اصفهان، اصفهان، ایران.
چکیده
دارورسانی هدفمند می‌تواند نقش مهمی در کاهش عوارض و درمان سرطان استخوان ایفا کند. در مطالعه‌ی حاضر، دوکسوروبیسین پخش‌شده در یک ماتریس پلیمری کیتوسان از طریق رسوب‌گذاری الکتروفورتیک بر روی یک پوشش فسفات کلسیم حاوی نانوذرات اکسید روی اعمال شد. پوشش پایه‌ی فسفات کلسیم توسط اکسیداسیون الکترولیتی پلاسما (PEO) بر روی داربست‌های Ti6Al4V ساخته‌شده از طریق ساخت افزایشی (AM) رسوب داده شد. رسوب‌گذاری در ولتاژ و ‌زمان بهینه 30 ولت و 10 دقیقه انجام شد، پس از آن پوشش‌ها ارزیابی شدند. نتایج نشان داد که پوشش با موفقیت بر داربست‌ها اعمال شده و پوشش زیرین به دلیل ماهیت روش PEO و پوشش رویی به دلیل حضور در حفرات پوشش PEO و پیوند عرضی ایجاد شده در نتیجه استفاده از تری سدیم فسفات، چسبندگی قویایجاد کرده است و همچنین در همه جای سطح حضور دارد. همچنین آب‌دوستی افزایش‌یافته نسبت به پوشش پایه را نشان داد. علاوه بر این، سمیت محلول از ۹۲٪ (کنترل) برای نمونه‌ی پوشش‌داده‌شده با اکسیداسیون الکترولیتی پلاسما به حدود ۳۲٪ (کنترل) برای نمونه‌ی پوشش‌داده‌شده‌ی دولایه کاهش یافت، که نشان می‌دهد این پوشش باعث پیری سلولی و در نهایت مرگ سلولی در سلول‌های MG-63 می‌شود. بنابراین، سیستم پوششی توسعه‌یافته پتانسیل امیدوارکننده‌ای برای کاربردهای ارتوپدی، به‌ویژه در درمان موضعی سرطان استخوان، به‌دلیل آزادسازی کنترل‌شده‌ی دارو و زیست‌سازگاری بهبودیافته نشان می‌دهد.
کلیدواژه‌ها

موضوعات


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